Amen...

Long week and it is only Wednesday morning.

I am too tired, depressed and sore to write so..
Here is another email from JH..
I will try to actually type something tonight or tomorrow.
Newest symptoms are hand m muscles locking up and I sweet like a water fall as soon as i start struggling with anything. I don even have to be moving. Once i start to slow down and things start going in slow motion i start sweating like I'm in a Marathon.
I am out of my trimodal for pain, so I am struggling to even move today.
Hope everyone else has a better day than me..

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Special Offer from Johns Hopkins Health Alerts * * * * * * * * * * * * * * * * * * * * * * * * * * * * Diagnosing and Treating Alzheimer's Disease This report from Johns Hopkins Medicine provides all the facts you need to make informed decisions if you have to confront Alzheimer's disease - the most common cause of dementia. With the passage of time, most of us will notice changes in our memory or thinking. But while forgetfulness is a normal part of getting older, dementia - and Alzheimer's disease specifically - is not. Yet we all worry. And not without reason. Today, one in ten people 65 and older has Alzheimer's disease (AD) - about 5 million of us - yet only half of these people have actually been diagnosed with the disease. The rest don't even know they have it! And it's estimated that by 2050 as many as 16 million of us will have Alzheimer's. We read these statistics and think, "When (not if) will it happen to me or someone in my family?" * * * * * * * * * * * * * * * If you're concerned because you've experienced recurring "senior moments". . . if you have any history of AD or related memory disorders in your family. . . if a loved one has been showing signs of memory loss that concern you. . . if you are caring for someone recently diagnosed with Alzheimer's and are wondering about a new drug or therapy. . . Then it's critically important to learn everything you can about this devastating disease now so you can make informed decisions about getting the correct diagnosis and treatment - so you can partner with your doctor effectively, ask the right questions, and understand the answers. The GOOD NEWS is that for most people, Alzheimer's progresses very slowly. Deterioration of thinking, memory, and judgment are gradual, often taking place over many years. So you have time to learn about Alzheimer's, to make the best treatment choices, and to plan for the future. To help you, we asked Peter V. Rabins, M.D., M.P.H., to share his wisdom and hands-on experience with Alzheimer's patients in a new in-depth report, Diagnosing and Treating Alzheimer's Disease. Director of the Division of Geriatric Psychiatry and Neuropsychiatry, and Richman Family Professor at the Johns Hopkins School of Medicine, Dr. Rabins is Medical Editor of the Johns Hopkins Memory Bulletin and co-author of The 36-Hour Day - and his expertise ensures that you get straightforward, reassuring, informed answers to your most important questions. This information is so crucial to your decision-making process that Diagnosing and Treating Alzheimer's Disease is available to you instantly in a digital PDF download. Simply click the order button below, and in a few moments you can begin reading! In the 104 years since Dr. Alois Alzheimer first described the symptoms of the disease, much has happened in brain research - but not enough. We still don't have an easy way to diagnose AD with complete accuracy, nor do we have a cure. What do we know? In Diagnosing and Treating Alzheimer's Disease, you'll learn how AD is currently diagnosed. . . the existing drugs that are used to treat it . . . and various new therapies that may some day provide better treatment. You'll learn answers to key questions, such as: What is the current thinking about the cause of Alzheimer's disease? What is the amyloid hypothesis and why is it under attack? Are amyloid plaques and neurofilbrillary tangles the cause of Alzheimer's or a byproduct of some other cause? How does beta-secretase prevent the build up of beta-amyloid? What happens when cholinergic neurons in the brain die? What's the difference between having a genetic predisposition to Alzheimer's and carrying a genetic mutation for Alzheimer's disease? What's the role of APOE in the formation of amyloid plaques? Does depression increase a person's risk of developing Alzheimer's? What about head injury? Studies suggest that lower early life education increases the risk of AD. Why? Where Does Normal Forgetfulness End and Mild Cognitive Impairment Begin? Some experts think that mild cognitive impairment (MCI) is the earliest manifestation of Alzheimer's. There is no definitive test for diagnosing AD (other than an autopsy) - but clinical information from the patient's history and mental status exams are accurate about 90% of the time. In Diagnosing and Treating Alzheimer's Disease, Dr. Rabins explains how the Mini-Mental State Exam (MMSE) - a 17-item test that assesses general cognitive function - and other tests are used to screen for Alzheimer's. You will learn about laboratory tests that can aid in the diagnosis of AD, including: Admark Assays... testing for APOE type... and the "sniff test," a promising diagnostic tool currently under study. Additionally, Dr. Rabins clearly explains the use of MRI, fMRI, SPECT, PET, and CT - high tech brain scanning and imaging techniques that can help in detecting early AD. Aricept, Razadyne, Exelon, Namenda - Do They Work? After screening for Alzheimer's, then what? Currently, we have four "symptomatic therapies" for Alzheimer's disease - drugs that can improve symptoms better than a placebo, but cannot cure patients or reverse the disease. Researchers estimate that only about 15% of AD patients actually take these meds. Why? Should you or your loved one take medication? What are the risks? Diagnosing and Treating Alzheimer's Disease gets to the heart of these questions: we explore in depth the arguments for and against these AD drugs... explain the benefits and common side effects of each drug... and answer frequently asked questions on the minds of many Alzheimer's families: How do you determine which patient should be using an Alzheimer's drug? How long to cholinesterase medications actually help? What happens if the patient does not respond to the medication? If one drug doesn't work, should the patient try another? If the cholinesterase inhibitors are considered safe and efficacious, why are so many Alzheimer's patients untreated or else taken off the drugs after just a short time? What's in the pipeline? You'll read about: Dimebon (latrepirdine) - a promising experimental drug that helped to slow cognitive decline inn Russian studies, but failed in recent Phase III trials. Our in-depth discussion explains what went wrong with Dimebon and why. CERE-110 - Currently the gene therapy trial for CERE-110 is recruiting for a new Phase II study. You'll learn how CERE-110 works and how to get involved. Davunetide - a novel spray to prevent Alzheimer's disease is being evaluated in human clinical trials as a treatment not only for Alzheimer's, but also for schizophrenia, cognitive impairment, and frontotemporal dementia. Statin Therapy, Anti-Inflammatory Drugs, and Estrogen - All have been investigated to treat Alzheimer's disease. Where do we stand? There's more to Diagnosing and Treating Alzheimer's Disease, much more. In page after page of this comprehensive report, we hone in on your most serious concerns about living with or caring for a patient with Alzheimer's. For example, depression in Alzheimer's patients is common. It doesn't appear like you'd expect it to, but it tends to respond to treatment. Dr. Rabins's colleague, Constantine G. Lyketsos, M.D., M.H.S., Director of the Memory and Alzheimer's Treatment Center at Hopkins, offers in-depth guidance on this crucial topic. Is depression an early symptom of Alzheimer's disease? Should you tell a patient that he or she has Alzheimer's? How is depression diagnosed in the Alzheimer's disease patient? When is the right time to introduce medications to treat depression? Could antidepressants aggravate Alzheimer's disease? What effect do antidepressants have on the biology of Alzheimer's disease? To add special value to this report, Dr. Rabins answers dozens of real-life questions from family members asking about specific concerns, symptoms, and issues regarding memory loss and dementia - the same questions that are on YOUR mind now as you search for practical advice to guide you in making decisions. Direct to You From Johns Hopkins Medicine Diagnosing and Treating Alzheimer's Disease is designed to give you unprecedented access to the expertise of the hospital ranked #1 of America's Best Hospitals for 21 consecutive years by U.S. News & World Report. You simply won't find a more knowledgeable and trustworthy source of the medical information you require. A tradition of discovery and medical innovation is the hallmark of Johns Hopkins research. Since its founding in 1889, The Johns Hopkins Hospital has led the way transferring the discoveries made in the laboratory to the administration of effective patient care. No one institution has done more to earn the trust of the men and women diagnosed with Alzheimer's and related dementias. Diagnosing and Treating Alzheimer's Disease draws on the extensive experience of Dr. Peter V. Rabins, who has spent his career studying psychiatric disorders in the elderly. If his name is familiar, it's probably as the co-author of the acclaimed book The 36-Hour Day, which since 2001 has been the bible of families caring for Alzheimer's patients. Dr. Rabins is the Richman Family Professor of Alzheimer's and related Diseases, Professor of Psychiatry, and Director of the Division of Geriatric Psychiatry and Neuropsychiatry at the Johns Hopkins School of Medicine. Still not sure you'll benefit from this Special Report? No problem... Our No-Strings, Can't Lose, Must-Be-Satisfied Offer! Diagnosing and Treating Alzheimer's Disease comes with a risk-free guarantee of satisfaction: if you're not satisfied for any reason, simply contact Customer Service within 30 days for a prompt refund of your full purchase price of $29.95. So you risk nothing. Don't hesitate - arm yourself with the facts about Alzheimer's disease. Place your risk-free order today. ORDER NOW You are receiving this email as part of your free subscription to Johns Hopkins Health Alerts. 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